Download The Development of a Medicine by R. B. Smith (auth.) PDF

By R. B. Smith (auth.)

Show description

Read or Download The Development of a Medicine PDF

Best administration & medicine economics books

Decision Analysis for Healthcare Managers

The 1st a part of the ebook explains a few of the analytical instruments that simplify and speed up choice making. find out about instruments that assist you ensure motives, overview offerings, and forecast destiny occasions. For events whilst a gaggle, instead of somebody, has to come to a decision, additionally, you will research what instruments may also help create workforce consensus.

Hospital Emergency Response Teams. Triage for Optimal Disaster Response

''. .. an exceptional place to begin for somebody approximately to embark at the technique of development a decontamination application in his or her facility. ''--Anjanette Hebert, Director of safety and security, Lafayette basic scientific middle, Lafayette, l. a.

Additional info for The Development of a Medicine

Example text

I I I I I Day 15 post coitern Spermatoqeoes s I I I Repro. Cycle of Rats I I I I I I I Day 6 - 15 post coton I I I I , , : II , I I I t I I I I I I I I 9 I. and Postnatal Developmeot ,, Day 13 post cortum kltled 112 I I _ EmbryotoxlCity Study Reprod . Pertormance ,, .... I I Pregnancy I --- ',~Parturition (day O. l Weaning (da y 21 post parlum) A~~ Figure 28 Showing how, geared to the reproductive cycle of the rat (shown below), the animals are dosed in order to expose them to the influence of the new drug at distinct phases of their lives.

Radio-labelled compound (depending upon the compound's characteristics labelled with carbon 14 or other radioactive isotope) both orally and intravenously. These studies are normally performed in dogs, rats and monkeys and the end result of these investigations will be to confirm what are the likely peak plasma levels following (initially) single doses of varying amounts. Distribution Once absorbed within the body, the distribution of the compound is clearly important. Whether the compound passes the blood-brain barrier or, indeed, whether there is untoward accumulation in one or more tissues or body sites, could well be significant in later development.

Lead will depend upon the mixture of skills available to a pharmaceutical company, the philosophy of its scientists, its cash resources and the imagination and courage of its leadership. BIOLOGICAL In practice , biological characterisation, safety evaluation and proof of efficacy are closely intertwined and therefore both this and following sections should be read with this constantly in mind. But, because so much work takes place coincidentally it is extremely difficult , and perhaps in the long run not very Basic Scientific Characterisation 33 helpful, to break it down artificially.

Download PDF sample

Rated 4.20 of 5 – based on 11 votes