By P. K. Stumpf
A pleasant deal with on plant biochemistry
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29 2 Enzyme Flexibility as a Molecular Basis for Metabolic Control JACQUES RICARD I. I n t r o d u c t i o n I I . F e e d b a c k R e g u l a t i o n of M e t a b o l i c P a t h w a y s I I I . P h e n o m e n o l o g y of t h e R e g u l a t o r y B e h a v i o r of E n z y m e s . A . T h e C o n t r o l P r o p e r t i e s a s Defined with R e s p e c t to L i g a n d Concentration B . T h e C o n t r o l P r o p e r t i e s a s Defined with R e s p e c t to T i m e IV. Molecular Devices That Command the Regulatory Behavior A .
K . (1969). Plant Physiol. 44, 5 0 8 - 5 1 6 . J a c o b s o n , Β . S . , S m i t h , Β . Ν . , E p s t e i n , S . , and L a t i e s , G. G. (1970). J . Gen. Physiol. 55, 1-17. J a m e s , W . O . (1953). " P l a n t R e s p i r a t i o n , " p p . 4 0 - 8 1 . Oxford U n i v . P r e s s , L o n d o n and N e w York. J a m e s , W . O . , and R i t c h i e , A. F . (1955). Proc. R. Soc. London, Ser. Β 143, 3 0 2 - 3 1 0 . K a l r a , S. K . , and B r o o k s , J. L . (1973). Phytochemistry 12, 4 8 7 - 4 9 2 .
Moreover, there is an obvious correspondence between neo-Darwinian evolution and the trial-and-error aspects of engineering devices. It is therefore not surprising that biological control systems can be modeled with electronic devices. In this chapter the role of enzyme flexibility in the regulation of metabolic pathways has been considered in a rather general way, and the attention has been focused on general concepts without too much concern to the details of individual enzyme systems. This type of approach has probably introduced a somewhat biased selection of references for discussion.